Drug Solubility: Importance and Enhancement Techniques
نویسندگان
چکیده
منابع مشابه
Drug Solubility: Importance and Enhancement Techniques
Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. Mor...
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Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. The major problem encountered with formulation development of new chemical entities as well as for the generic development is low aqueous solubility. It ...
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Over 40% of active pharmaceutical ingredients in development are poorly water soluble drugs which limit formulation approaches, clinical application and marketability because of their low dissolution and bioavailability. Solid dispersion has been considered one of the major advancements in overcoming these issues with several successfully marketed products. Extensive review of the literature in...
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The low aqueous solubility of celecoxib (CB) and thus its low bioavailability is a problem. Thus, it is suggested to improve the solubility using cosolvency and solid dispersions techniques. Pure CB has solubility of 6.26±0.23μg/ml in water but increased solubility of CB was observed with increasing concentration of cosolvents like PEG 400, ethanol and propylene glycol. Highest solubility (791....
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The enhancement of solubility of a solid in a supercritical solvent is interpreted with emphasis placed on binary mixtures of the second class. The selection of supercritical solvent ; the choice of temperature and pressure for supercritical fluid extractions; the characteristics of solubility curves between and in the vicinities of the upper critical and the lower critical end points; the effe...
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ژورنال
عنوان ژورنال: ISRN Pharmaceutics
سال: 2012
ISSN: 2090-6153
DOI: 10.5402/2012/195727